Microbiology and Immunology 2500A/B Lecture Notes - Lecture 22: Orthomyxoviridae, X-Ray Crystallography, Avian Influenza
29 Sep 2017
School
Department
Document Summary
Understand how viruses make it into the cell: Concept of entry: recognition of host cell receptor (attachment, mechanism to release the genome (for example into the cytoplasm) Basic but key concept 3: the virion must be both stable and unstable. The stability varies during different times during the infectious cycle: once attached to the susceptible and permissive cell: most stable, stability is lost when we start to lose the particle or the capsid. On right: initiation of the viral infectious cycle. Resistant cell: no receptor; may still support replication though. For many viruses there is a strict requirement for a coreceptor: coreceptors are second receptor: primary receptor + secondary receptor (coreceptor, very essential for many viruses (exclusing yeast and plants, such as hiv. Host cell receptors: (large) variety of host cell viral receptors. In some cases, the same receptor can recognize more than a single.
