Microbiology and Immunology 2500A/B Lecture Notes - Lecture 13: Intracellular Parasite, Icosahedral Symmetry, Icosahedron

• School: Western University
• Department: Microbiology and Immunology
• Course: Microbiology and Immunology 2500A/B
• Professor: Dr.Summers

Document Summary

Lecture objectives: understand how viruses make it into a host cell, elements, overview and concept, viral receptor attachment, host cell entry (enveloped and non-enveloped viruses, nuclear viral entry. Recognition of host receptor attachment and get inside: 2. In some cases, a second receptor is required co-receptor: very, very essential for many viruses (excluding yeast and plants) Host cell receptors come in many flavours: key: variety of host cell viral receptors. In some cases, the same receptor can recognize more than a single virus and vice. Pvr = polio virus receptor: note that these same receptors have other functions inside the cell (not just waiting there to be infected by viruses viruses have adapted to use them) Two different modes of attachment: the (cid:373)ode of atta(cid:272)h(cid:373)e(cid:374)t (cid:449)ill depe(cid:374)d o(cid:374) (cid:449)hat the outer (cid:862)shell(cid:863) of the (cid:448)irus is, there are enveloped viruses and non-enveloped viruses. Non-enveloped viruses with icosahedral symmetry: picornaviridae poliovirus.