Microbiology and Immunology 2500A/B Lecture Notes - Lecture 4: Hepatocyte, Acute-Phase Protein, Neutrophil
18 Jun 2016
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Document Summary
* hematopoietic stem cell in bone marrow can become either lymphoid or myeloid stem cell. * cytokines tell the stem cell to go which route. * when a cell gets activated, it release a bunch of cytokines at the same time. * any time there is a binding interaction, there is an activation of the cell. * prr-pamp triggers phagocytosis, but also phagocyte ends up secreting cytokines (key ones are tnf, il1, il6, and chemokines) * pathogen somehow enters into your tissue (it"s an ec pathogen) * phagocytes will immediately start phagocytosing (macrophages and dendritic cells) * pro-inflammatory ones, tnf, il1, il6, activate endothelial cells (cells that line the blood vessels) * endothelial cells have gaps, don"t have tight juncs because we need nutrients to leak out into our tissues (e. g. o2) * also waste products go back into bloodstream (e. g. co2) * when that endothelial cell gets activated, it vasodilates, so there is increased diameter of blood vessel.
