Microbiology and Immunology 2500A/B Lecture 3: Immunology 3

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Main barrier: skin is first line of defense as long as it is intact (no sores/cuts) All have same barriers/no one is unique wrt innate immune system. This is different with adaptive immune systems immediate response. Innate immune system responds the same way whether it is 1st. Mouth largest opening to the body (most enter here) and through respiratory tract. Proliferate quickly to fill in gaps from damage. Antimicrobial peptides defensins send activation signal to epithelial cells. Defensins translated and secreted into environment to go back and attack cell walls of bacteria. Embed in cell wall of pathogen by forming a pore in the bacterial cell wall (a hole so things fall out of the cell and then the bacterial cell dies) Fluids eg: tears, vomiting, diarrhea, norwalk virus (expelling from both ends), urine (drink lots of water when sick to flush out virus), cilia (push it out), mucous.

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