Microbiology and Immunology 3300B Lecture Notes - Lecture 14: Inactivated Vaccine, Independent Community And Health Concern, Cervarix
9 Dec 2016
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Document Summary
Not a issue in many kids but 1/3 of cases with severe diarrhea requiring treatment. Very significant problem in the developing world without ready access to extensive. Common childhood infection worldwide health care afghanistan, chad, somalia 500,000 child deaths/year = serious. 1998 vaccine approved; trials suggest significant impact on diarrhea- Intussusception intestine folds in on itself: death common without treatment, but <1% in 1st world, 1:2000 population risk, in depth post-approval analysis suggested 1:10,000 population. Mexico: 35% reduction - reduced hospital visits for diarrhea the same amount rotavirus was expected to cause (35-40% of cases) related childhood deaths attributable risk with vaccine went from 5:10,000 to 6:10,000/year. Within a year, the virus for rotavirus was pulled because of this risk. Lessons from rotashield: first world problems, third world needs. Result is that we get to decide for the rest of the world what vaccines are produced. Most deadly diseases have vaccines already *deadly to first world.
