Microbiology and Immunology 3300B Lecture Notes - Lecture 1: Phagocytosis, Gata2, Monocyte
9 Dec 2016
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Tutorial 1: clinical studies mycobacterial infection (monomac): hematopoiesis in 2 families (very rare) Nk cells are found in decreased numbers or can be totally deficient in a number of hematopoietic disorders. Non-immunological symptoms: impaired dna repair (high cancer), glucocorticoid deficiency (developmental defects, attention deficits, anti-inflammatory), failure to thrive syndrome (poor growth/stature), clinodactyly (deformed/bent fingers), hyperpigmentation. Monocytopenia (=low monocytes), lack all nk cells, low numbers of b-cells, susceptible to broad range of viral and bacterial pathogens (*predominantly intracellular), high rates of cancer. Mcm4 deficiency: (= minichromosome maintenance complex component 4) Often associated with other immune cell deficiencies e. g. monocytopenia and. Mutation in gata2 key tf in differentiation of immune cell types during. Deficiency that affects nk cells derived from lymphoid progenitor cells identified. Result of inbreeding cousins having kids, kids have this deficiency. Mcm(cid:886) is severe depletion of nk cells, but doesn"t effect other lymphocytes. B-cells and t-cell numbers between the two groups is normal normal levels.
