Microbiology and Immunology 3300B Lecture 6: Lecture 6 - Inflammation
9 Dec 2016
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Document Summary
A good thing when it"s working but can be bad if not regulated properly. Inflammation = innate immune response characterized by accumulation of fluid, plasma proteins and immune cells at the site of tissue damage or infection. Generally considered innate, but there is input from adaptive. Postcapillary venules after the capillary network collecting blood from capillaries. Bcs travel through circulatory system, but when bacteria gets in and replicates and produces toxins, that has an effect on local tissue resident antigen presenting cells. Pamps activate prrs and tlrs and produce cytokines, which then act on endothelium cause it to attract any immune cell that"s migrating through to migrate towards the site of inflammation. Neutrophils then migrate towards, phagocytose those microbes and degrade them. Also get liberation of chemical mediators, mainly cytokines to enter circulatory system, could also act upon the liver (il6) which acts on liver hepatocytes which produce acute phase proteins (opsonins to opsonize bacteria to be recognized)
