Microbiology and Immunology 3300B Lecture Notes - Lecture 4: Map3K7, Death Domain, Interleukin 2
9 Dec 2016
School
Department
Professor
Document Summary
Pamps are molecules on pathogens that are evolutionary conserved because they. Gram-negative (e. coli) has outer membrane and inner membrane with membrane lps + peptidoglycan are pamps. Gram-positive bacteria (staphylococcus aureus) has much larger peptidoglycan, and has glycolipids (lipitichoic acid) and glycoproteins (di/triacyl lipoproteins)= pamps. Prrs found on many different types of cells recognize pamps need them for their lifestyle or replication pathogen can(cid:495)t dispense with it. We(cid:495)ve derived prrs to identify these molecules peptidoglycan in between lipopolysaccharide (lps- endotoxin) on outer. There are entities within microbes that can also act as pamps genetic material. Bacterial and viral dna doesn(cid:495)t have methylated cysteines = pamp. We don(cid:495)t have double stranded rna, they do can decipher between. We don(cid:495)t have endosomal rna or dna have prrs in our endosomes to recognize (cid:494)odd(cid:495) uncapped rna. Also produce profilin protein we produce it too but its different than fungi kind. These are germ line encoded we don(cid:495)t require dna recombination event to.
