Microbiology and Immunology 3300B Lecture Notes - Lecture 6: Thymocyte, Lymphopoiesis, Antigen
9 Dec 2016
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Cd3 and the chains have intracellular segments and can induce a signal going to attack and how its going to do it coordinate and interact with other cells. Wont get signaling until corecptor, cd4 or cd8, is recruited into the complex, associated with kinase lck, phosphorylates itam which allows recruitment of other proteins and assembly of complex initiates signaling. Bcell through bcr can directly bind antigen, t-cell requires third party apc that. T-cell doesn"t act alone, it has a lot to do with deciding what the immune system is. Looks like a membrane bound fab fragment alpha and beta chains. Variable and constant regions of each cdr1, 2, and 3 in the v region. Can"t signal itself, mediated through a molecular complex, associates with cd3 collection of various chains. Tcr: peptide: mhc binding large complex of molecules: cuts it up and presents peptides on mhc needs to recognize both peptide and mhc.
