Microbiology and Immunology 3300B Lecture Notes - Lecture 31: Antibody, Phosphocholine, Transcytosis
20 May 2016
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Document Summary
Acquired (induced) tolerance: the suppression of a specific, systemic immune response to foreign antigens induced by the specific actions of lymphocytes. Fetal tolerance: the suppression of a specific systemic immune response to foreign antigens found within a developing fetus. Oral tolerance: the suppression of a specific, systemic immune response against antigens encountered via the enteric (oral) route. Deletion or editing of self reactive lymphocytes. Most self antigens are retained outside of the lymphoid system by physical barriers (cell membranes, endothelium, etc) In the absence of tissue damage, these antigens are not encountered by immune cells. These are sites capable of tolerating the introduction of an antigen without eliciting a damaging immune response. Tissue grafts into these tissues can survive without immunosuppressive drugs. Expression of class ib mhc in preference to classical mhci: these mhc present formyl peptides and don"t express self antigens usually. Production of tgfb which is the anti inflammatory cytokine.
