Microbiology and Immunology 3300B Lecture Notes - Lecture 10: Beta Sheet, Antibody, Epitope
20 May 2016
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Document Summary
B cell receptors and antibodies consist of four polypeptide chains linked by disulphide bonds. Antigen binding region: highly variable amino acid sequence. The domains of an immunoglobin molecule are structurally similar. All of them are composed of beta strand arrangements. On the vl (variable domains: have beta pleated sheet structures called the complimentary determining regions, made up of 7 different antiparallel regions. Epitope (aka antigenic determinant) portion of the antgen recognized by an antibody or. Paratope: unique surface topology at the ends of an antibody that is complimentary to the epitope. Bcr = huge diversity of things it can recognize. Antigens can have multiple epitopes: therefore multiple paratopes can bind onto one antigen (potentially) Chemically synthesized organic molecules occurring in nature, conjugated to protein. Could demonstrate synthesis in the animal of antibodies specigically recognizing the molecule. And what cells make these antibodies: could generate antibodiesfrom any given molecule. Recognize things as small as a phenol ring.
