Microbiology and Immunology 3820A Lecture Notes - Lecture 2: Blastomyces Dermatitidis, Histoplasma, Genitourinary System
9 Dec 2016
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Document Summary
Have the ability to grow as both yeasts and molds, depending on the conditions. Acquired by the inhalation of airborne spores from soil. White cottony colonies which turn brown with age. At 37*c in the brain, heart infusion broth with 10% sheep blood it forms small ovoid narrow based budding yeast cells. Forms narrow ovid yeast which are not very distinctive but in their fungal form they form these spore like bodies that are very distinctive. Large spores, tubercules coming off them is the way we identify them. Aquired by inhalation of spores from soil heavily contaminated with bird or bat droppings. Usually self limited, but commonly causes scarring of the lungs which can present as. Can disseminate into reticuloendothelial system (liver, spleen, bone marrow) Yeast forms large double-walled, wide based budding forms. Initial pulmonary infection can disseminate to ski (70%), bone (30%) and genitourinary tract (20%) Primary subcutaneous infection is associated with wood slivers and dog bites.
