Microbiology and Immunology 3820A Lecture Notes - Lecture 5: Hematopoietic Stem Cell Transplantation, Gamma Globulin, Granuloma
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4 Mar 2016
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Lecture 5 - t cell- mediated immunity. Recall bcr binds directly to its specific antigenic epitope. Tcr only binds protein antigens. Tcr must be presented with antigenic epitope on a major. Mhc class 1 molecules bind to endogenous peptides. Epitope = a peptide derived from a protein antigen. Every na ve t cell expresses a variable region specific for one unique peptide (antigenic epitope) 2 classes of mhc molecules. Mhc class 2: peptide complex. Peptides are generated from proteins inside a cell, which is where they bind to mhc molecules. Peptides transported to the surface of the cell and waits for a t cell to bind. Endogenous peptides are derived form intracellular pathogens (red bacteria, virus) Pathogen replicates in the cytoplasm of infected cell. Endogenous means within the cell. Tcr of cytotoxic t cells recognize peptides bound to. Exogenous peptides are derived from extracellular pathogens. Mhc class 2 molecules bind to exogenous peptides.
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1. | In people infected with human cytomegalovirus, class I MHC andb2-microglobulin are produced, but very little mature class I MHCis found at the cell surface. Inhibition of which of the followingmolecules by human cytomegalovirus may account for thisphenomenon? | ||||||||||
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2. | Your chances of having the same MHC haplotype as your siblingare: | ||||||||||
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3. | Which of the following is the BEST example of self-MHCrestriction of T cells? | ||||||||||
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4. | MHC molecules: | ||||||||||
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5. | Tasmanian devils are a largely inbred population with littlediversity in the MHC. Which of the following would be a likelyoutcome of this? | ||||||||||
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6. | How many different MHC classical class I proteins does eachnucleated cell in a human heterozygous at the MHC locusexpress? | ||||||||||
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7. | MHC polymorphisms tend to cluster: | ||||||||||
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8. | A mutation that renders the MHC class II molecule DMnonfunctional would likely lead to: | ||||||||||
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9. | The human MHC locus is one of the most polymorphic regions ofthe genome. What does this mean? | ||||||||||
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10. | Which of the following is an example ofcross-presentation? | ||||||||||
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