Microbiology and Immunology 3300B Lecture Notes - Lecture 5: Enterocyte, Extracellular Fluid, Basal Lamina
3 Mar 2018
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Primary includes bone marrow, thymus / secondary consists of spleen, lymph nodes, mucous associated lymphoid tissues (malts) Thymus, bone marrow (any long bones in the body like hips, femur, ribs, scalp, etc. ) In case of b cells where b cells generate bcr/ t cells generate tcr in primary. Bone marrow where b cells are born. B cells rearrange their antibody genes to make viable bcr. Important cell types: osteoblasts: generate bone and control hsc differentiation, endothelial cells: line the blood vessels, reticular cells: processes connect cells. Immune cells develop in cavities between bony trabeculae: spiny structures all throughout the bone = trabeculae. Biopsy showing areas of hematopoietic marrow (hm) in the spaces b/w bony trabeculae (t). Some of the space is occupied by adipocytes (adc, white areas: h&e stain; t and b cells generated seen, need lots of energy to make wbc hence why adipocytes are present.
