Immunology Notes

3 Pages

Microbiology and Immunology
Course Code
Microbiology and Immunology 3300B
Rodney Dekoter

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Immunology NotesOct 2712 Immature dendritic cells are tissue resident and are specialized for antigen uptake DCs can take up extracellular bacteria through receptormediated phagocytosis and can take up extracellular bacteria soluble antigens and virus particles through macropinocytosis These antigens can be presented on MHC class II molecules to CD4 T cells Antigens from intracellular viruses can be presented on MHC class I molecules to CD8 T cells Cross presentation can also occur when exogenous viruses are taken up by phagocytosis and presented on MHC class I to CD8 T cells Cross presentation is important so there are several pathways for it to occur Maturation of iDCs is induced through innate recognition of pathogens iDCs in peripheral tissues encounter pathogens and are activated by PAMPs iDCs contain many phagocytic receptors such as DEC205 DCsign mannose receptor dectin1 Upon exposure to pathogen TLRs become activated TLR signalling induces CCR7 and enhances processing of pathogenderived antigens Expression of CCR7 makes the DC sensitive to the chemokines CCL21 and CCL19 produced by lymphoid tissue and induces migration of DCs through the lymphatics and into the local lymphoid tissues CCL21 and CCL19 also provide further maturation signals which result in higher levels of costimulatory molecules B7 and MHC on the cell surface DCs are found throughout the body Langerhans cells are a type of DC found in epidermis They take up antigen in the skin then enter the lymphatic system and migrate to the lymph nodes Once there they differentiate into mature DCs and transfer some antigen to resident DCs for presentation to naive T cells The chemokines CCL21 and CCL19 are expressed by HEV and bind to CCR7 on nave T cells which helps their entry into lymph nodes Activation of a naive CD4 T cell occurs in the T cell zone of secondary lymphoid tissue through interactions
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