Pathology 3240A Lecture Notes - Lecture 10: Squamous Cell Carcinoma, Benign Tumor, Epithelium
4 Dec 2016
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Definition of biopsy, hemidissectomy (listen to first 5 min) Injure a cell => two outcomes: dead or alive. If cell is alive, will try to adapt to it => atrophy (dec in size) or. = conversion of one differentiated cell type to another: although it is a protective mechanisms there may be loss of function. Ie gastroreflux disease: epithelium changes, regular columnar cell change into intestinal columnar cell: bronchial ciliated columnar epithelium to squamous epithelium in smokers. Dysplasia (most important change when it comes to cancer) = alteration in size, shape and organization of the cellular components of a tissue. Features: variation in shape and size of cells, enlargement of cells (bcz more dna), irregularity and hyperchromatism of the nuclei. A pre-malignant condition (cid:894)if do(cid:374)"t treat this (cid:449)ill de(cid:448)elop i(cid:374)to full gro(cid:449)(cid:374) (cid:272)a(cid:374)(cid:272)er(cid:895) Disordered arrangement is a premalignant lesion (no invasion is present) Persistent injury may lead to dysplasia: dysplasia in bronchial epithelium, ^ in cervical epithelium.
