Pathology 3240A Lecture 8: Hemodynamics
15 Oct 2018
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Document Summary
2/3 of body fluid is intracellular, and 1/3 of body fluid is extracellular (plasma and interstitial fluid). Survival of cells and tissues is dependent on oxygen provided in the blood supply and normal fluid balance. Systemic factors (intact circulation, overall fluid balance, salt retention) Homeostasis: process of maintaining a constant internal environment despite changing external conditions. Altered vascular homeostasis results in changes in net movement of water across the vascular wall. Lymphatic system: each day about 50% of the total blood proteins leak out of the capillaries into the tissue fluid and return to the blood via the lymphatic vessels. Under normal circumstances, only a small amount of fluid leaks from vessels to the interstitial fluid, which is removed by lymphatic vessels. Starling"s law: movement of fluid between vascular and interstitial spaces at level of capillaries is controlled by 4 forces (mainly hp and op): Forces exerted by a fluid against the capillary wall (pushing force)
