Pathology 3240A Lecture Notes - Lecture 1: Immunofluorescence, Respiratory Disease, Cholera
10 Nov 2015
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Its literally meaning is the study of suffering and illness. Look at cell samples to determine cancer: clinical support: pathologists provide guidance in treatment, ex. Staging cancer again using samples: autopsy: determining the cause of death, forensic autopsies (medical and legal factors, research: experimental pathology, mechanisms, complications and sequelae of disease, models of disease (animal or human tissue) Techniques for diagnosis in pathology: gross examination (macroscopic): examining specimen macroscopically, then taking sections to look under a microscope, ex. Esophagus sample is removed by surgeon and goes to autopsy lab where a pathologist determines throat cancer: light microscopy. 4: electron microscopy: ultrastructure of things rather than cells, we look at parts of cells. Immunofluorescence: using a fluorescent dye specific to the cancer. Key definitions: disease: the pattern of response of a living organism to injury. It is injury due to genetic insult or the environment where the cell fails to adapt to injury or is itself harmful in its adaptation.
