Pathology 3245B Lecture Notes - Lecture 10: Liver Function Tests, Common Hepatic Duct, Common Bile Duct

• School: Western University
• Department: Pathology
• Course: Pathology 3245B
• Professor: Patrick Howlett

Document Summary

State the inheritance pattern and pathologic substrate for the 3 major hepatijc metabolic and storage diseases discussed define intra and extrahepatic cholestasis state at least 1 risk factor for and histologic geature of pbc and psc differentiate calculous. Dual blood supply: hepatic artery, portal vein (comes from gastrointestinal tract tumours from gi tract can deposit ) Bile leaves the liver via the right and left hepatic ducts: join to form common hepatic dut which joins the cystic dut to become the common bile duct (cbd) Divided into hexagonal lobules: at the centre of each lobule is the central vein which join the hepatic veins > interior vena cava > heart, at periphery of the lobules are the portal tracts. Hepatic artery, portal vein and bile duct: the lobules consist of anastomosing sheets or cords of liver cells hepatocytes. Synthetic: most serum proteins (albumin, clotting factors, etc. ) but not immunoglobulins. Excretory: bile (important for fat absorption)