Pathology 3245B Lecture Notes - Lecture 2: Neural Tube Defect, Neural Groove, Neural Tube
25 May 2016
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Document Summary
Neuropathology brain doesn"t try to micromanage frontal lobe - personality, dementia in older people language function - temporal/parietal memory - temporal/medial (hippocampus) entire body starts off as single cell and becomes this neural plate embryo at 20 days (gestation) Cells in the brain (neurons/nervous system) is stationary/stability during adulthood. Developing brain needs to move around to form structure to end up as the end- organ; and making new connections. Neurons need connections (part of their trophic requirement) Cells need to migrate around, form connections and work within the network (need to be needed; if not connected, apoptosis and leave the system) Early on when still growing the brain, massively overpopulate it with cells; make way more cells than you need. Cells sent out to target, and prune back to what is needed and some cells degenerate. Wrappings of the cns: skin, fat, muscle, bone, meninges.
