Pathology 2420A Lecture Notes - Lecture 7: Myocardial Infarction, Coronary Artery Disease, Coronary Circulation
9 Dec 2016
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Document Summary
After completing this module you will be able to: explain the pathogenesis of atherosclerosis, atherosclerosis is a systemic disease affecting large and medium-sized arteries. The earliest pathological lesion is called a fatty streak. Chronic endothelial injury which results in endothelial dysfunction. Accumulation of lipoproteins in the vessel wall. Monocytes (macrophages) adhere to the endothelial lining and migration into intima. Release of growth factors and cytokines which cause recruitment and migration of smooth muscle cells and fibroblasts into the endothelium. Smc proliferation and ecm production (e. g. collagen is produced) Pathology final exam review: list and describe the major clinical manifestations/sequelae of atherosclerosis in heart (cad, angina, mi) and other organs, major sites of atherosclerotic ischemic injury and clinical disease are: Heart causing angina, myocardial infarction, chronic heart failure, sudden cardiac death. Angina chest pain result of myocardial ischemia, which is usually due to coronary atherosclerosis, usually at least one ca with a fixed stenosis although vasospasm can futher contribute to narrowing.
