Pathology 2420A Lecture Notes - Lecture 1: Neoplasm, Cleft Lip And Cleft Palate, Hypercholesterolemia
28 Feb 2017
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Document Summary
Congenital present at birth but not necessarily inherited. Chromosomal abnormalities change in # of chromosomes or structure. Disease change in normal body function to abnormal function. Pathogenesis the stages through which the disease progresses. Teratogen chemical, biological, or physical agent that causes defects in embryo. Life expectancy has slightly increased since turn of century. Improvments in sanitation, drug- related and surgical treatment has decreased the rate of mortality in recent years (most notably for heart and cerebrovascular diseases) Cancer is #1 cause of death followed closely by diseases of the heart. Diseases of the circulatory system are the #1 cause of hospitalization. Genetic diseases are due to genetic abnormalities. Genetic alterations can be single gene mutation (sickle cell disease) or rearrangements of whole chromosomes (trisomy 21) Genetic diseases can also be inherited (far less common than sporadic mutations) Congenital anomalies or abnormalities are structural deficits that are present. Environmental agents that produce abnormalities during embryonic/fetal development (i. e. infections, drugs, irradiation)
