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Lecture 33
Pathology 3500 Lecture Notes - Lecture 33: Spina Bifida, Intracranial Pressure, Neural CrestPremium
4 pages101 viewsSpring 2018
School
Western UniversityDepartment
PathologyCourse Code
Pathology 3500Professor
Jessica ShepherdLecture
33This preview shows page 1. to view the full 4 pages of the document.
Neuropathology
Lecture Objectives
● Gross and Microscopic anatomy
● Nervous system response to disease
● Cerebral herniation
○ Intracranial pressure
○ What happens to the brain if there is excess pressure
● Regeneration
● Common neurological syndromes
Brain (at birth)
● Pretty well developed
● Gyrus and sulcus
● Lobes
● Cerebellum
○ Balance and coordination
● Brainstem (and spinal cord)
○ Conduit for the brain
■ Output and input fibers
● Brain as lots of connection to make sure information is coordinated
Development of the brain
● Nervous system is developed from sepalized ectoderm
● 20 days
○ Flat plate of cells develops into the neural crest and neuro groove
● 24 days
○ Tube formation complete (merged in the midline)
■ Primitive nervous system
■ Closed
○ Some openings
■ Rhomboid sinus (bottom end)
● If closure of the tube is not completed
○ Spina bifida
○ Genetic and nutritional
○ Cells migrate a lot a this point
■ Brain is a metabolic active and mobile structure at this time
● Cell migration, proliferation at the north end
○ Ventricles
■ Lining of the tube
■ Neuron and glial cells are born here, have to migrate
Gross Neuroanatomy
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