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Lecture 33

Pathology 3500 Lecture Notes - Lecture 33: Spina Bifida, Intracranial Pressure, Neural CrestPremium

4 pages94 viewsSpring 2018

Department
Pathology
Course Code
Pathology 3500
Professor
Jessica Shepherd
Lecture
33

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Neuropathology
Lecture Objectives
Gross and Microscopic anatomy
Nervous system response to disease
Cerebral herniation
Intracranial pressure
What happens to the brain if there is excess pressure
Regeneration
Common neurological syndromes
Brain (at birth)
Pretty well developed
Gyrus and sulcus
Lobes
Cerebellum
Balance and coordination
Brainstem (and spinal cord)
Conduit for the brain
Output and input fibers
Brain as lots of connection to make sure information is coordinated
Development of the brain
Nervous system is developed from sepalized ectoderm
20 days
Flat plate of cells develops into the neural crest and neuro groove
24 days
Tube formation complete (merged in the midline)
Primitive nervous system
Closed
Some openings
Rhomboid sinus (bottom end)
If closure of the tube is not completed
Spina bifida
Genetic and nutritional
Cells migrate a lot a this point
Brain is a metabolic active and mobile structure at this time
Cell migration, proliferation at the north end
Ventricles
Lining of the tube
Neuron and glial cells are born here, have to migrate
Gross Neuroanatomy
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