Pathology 3500 Lecture Notes - Lecture 4: Contracture, Apposition, Connective Tissue
Document Summary
Introduction: when injury occurs, there is a chemically mediated vascular and cellular response, which results in acute inflammation both the injury itself and the inflammation cause tissue damage. If there wasn"t much tissue damage in the first place (no or minimal cell necrosis and tissue destruction), once the injurious agent is removed and inflammation subsides, the tissue is restored back to normal: complete resolution. If the ecm has not been damaged, the tissue may be capable of healing by regeneration because the cell proliferation can occur in the setting of an intact scaffold. If the ecm has been damaged, even cells that are capable of regeneration will be proliferating on a broken scaffold thus, will proliferate in haphazard ways, resulting in disorganized and non-functional tissues: example: liver. Liver has characteristic architecture under the microscope (as dictated by ecm: hepatocytes in the liver are stable cells with regenerative capabilities, arranged on an ecm scaffold.
