Pathology 3500 Lecture Notes - Lecture 8: Menopause, Erythropoietin, Immunohistochemistry
Document Summary
Introduction: every system in the body relies on the blood extremely important, artificial picture showing the different blood cell types, rbc anucleate cell. Increased respiratory rate: shortness of breath (sob) on exertion. If anemia stems from ineffective hematopoiesis, it is associated with inappropriate increase in iron absorption from the gut, which can lead to iron overload (secondary hemochromatosis) with subsequent damage to endocrine organs and heart. Classification the anemia: decreased production of rbcs, problem with bone marrow production, blood loss. Increased destruction of rbcs: not surviving for long enough (should be ~120days, morphological classification (3 main categories); based on, red cell size, can be too big or too small, red cell colour, abnormal shapes. If massive, can lead to cardiovascular collapse, shock, and death. In most cases of hemolytic anemia, the hemolysis is extravascular defective rbcs being destroyed: this is normal for old rbcs, but in hemolytic anemia, the rbcs are being prematurely destroyed.
