Pharmacology 2060A/B Lecture : Module 3 Notes.docx
11 Dec 2013
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Free drug distribution in compartments in body where stored, metabolized, Exert or excreted compartments: interstitial space (extracellular fluid surrounds cells) Low molecular weight/water soluble drugs: total body water. Interstitial space, intracellular fluid and plasma: plasma. Drugs bound to plasma protein, high molecular weight: adipose tissue (bodies fat) Crystal surface of bone into crystal lattice. Blood flow to tissues: rapid (kidney, liver, brain) well perfused, slow (muscle, bone, skin) low blood flow. Ability of drug to move out of capillaries: blood brain barrier = low ability. Ability of drug to move into cells: lipophillic to directly penetrate, or carried into cell by uptake transporter, some drugs removed by efflux transporter limit. Protective bc promotes excretion and protects body from exposure to drugs and toxins. Requires energy (atp) to move against concentration gradient. Liver: in between hepatocyte = bile canaliculus (route of eliminationno blood. Intestine: drugs from enterocytes back into central intestinal lumenno blood.
