Pharmacology 2060A/B Lecture Notes - Lecture 5: Renal Function, Renal Blood Flow, Distal Convoluted Tubule
9 Dec 2016
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Document Summary
Removal of parent drugs and drug metabolites form the body. Sites of excretion kidney, bile, lung, breast milk. The kidneys account for the majority of drug excretion. Healthy kidneys serve to limit the duration and intensity of drug effects. Decreased kidney function prolongs the duration of action and intensity of drug effects. The basic structural and functional unit of the kidney. Controls blood volume, blood pressure, blood ph and solute (including drug) excretion. 5. 2 factors affecting renal de: glomerular filtration. Drugs enter the kidney from the renal artery and afferent arteriole. Hydrostatic pressure within glomerular capillaries forces low molecular weight drugs leave blood supply into the renal tubules (determined by size of molecules) Glomerular filtration rate is ~ 120 ml/min/1. 73 m2 or about 20% of total renal plasma flow. Lipid solubility and ph do not affect glomerular filtration of drugs. Only non-protein bound (i. e. free) drugs are filtered at the glomerulus: tubular secretion.
