Pharmacology 2060A/B Lecture Notes - Lecture 11: Peristalsis, Enterohepatic Circulation, Enteric Coating
9 Dec 2016
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Document Summary
Drugs can interact with each other or components in our diet to produce. Drug-drug interactions may occur whenever a patient takes two or more drugs. Drug-food interactions may occur even if a patient is only taking one drug. The risk of drug interactions increases (almost linearly) with the number of medications a patient takes. Drug interactions are especially important in the elderly. The average 65 year old takes 7 medications, significantly more than the average 20 year old. The most common type of drug-drug interaction are those affecting pharmacokinetics (adme) When two drug or more drugs interact there are 3 possible outcomes: increased effects. Drug interactions can increase drug effects by either an increase in the therapeutic effect or an increased adverse effect. Ampicillin is an antibiotic that is rapidly inactivated by bacterial enzymes. Sulbactam is an inhibitor of the bacterial enzyme that inactivates ampicillin. Ampicillin rapid )nactivation, poor therapeutic response. Ampicillin + sulbactam )ncreased therapeutic activity of ampicillin.
