Pharmacology 2060A/B Lecture Notes - Lecture 10: Resting Potential, Patient Education, Spasm
13 Sep 2017
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Module 10 study notes adverse drug reactions and medication errors. Canadian research: 7. 5% of hospital admissions in canada are attributed to adverse drug reactions . Antihistamines: act by blocking h1 histamine receptors to prevent the symptoms of allergy, side effects of anti-histamine: drowsiness, dry mouth, urinary retention, diagram: histamine binding to the histamine receptor in sinuses causes vasodilatation . Intensity of allergic reactions are independent of dosage: ~10% of all adrs are related to drug allergy, few drugs cause allergic reactions. Stan marsh case study: oatp1b1, uptake drug transporter in the liver, 15% of asian and caucasian patients have a polymorphism that decreases function, leads to an increase in plasma drug concentrations. Many drugs exhibit toxicity to a specific organ. Organ specific toxicity can occur to the kidney, lung, heart, liver, muscle, inner ear, etc. Most common/important organ specific toxicity is observed in the liver and heart. Most common reason for an approved drug to be removed from the market.
