Pharmacology 2060A/B Lecture Notes - Lecture 3: Body Water, Extracellular Fluid, Adipose Tissue
21 Feb 2019
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Low molecular weight, water soluble drugs distribute in the interstitial space: total body water includes the fluid in the interstitial space, intracellular fluid and the plasma, plasma the non-cell containing component of blood. Drugs strongly bound to plasma protein and high molecular weight drugs typically distribute in plasma: adipose tissue the body"s fat. Lipid soluble (lipophilic) drugs distribute into adipose tissue: muscle some drugs bind tightly to muscle tissue, bone some drugs adsorb onto the crystal surface of bone with eventual incorporation into the crystal lattice. Bone can be a reservoir for the slow release of some drugs: other tissues, body compartments, we administer the drug by parenteral injection absorped directly into the plasma compartment, within the plasma compartment, drugs can exist as either. The outer portion of tumours has a high blood flow but the blood flow progressively decreases towards the middle.
