Pharmacology 2060A/B Lecture Notes - Lecture 9: Therapeutic Index, Single-Nucleotide Polymorphism, Median Toxic Dose
To be able to determine the ed50, td50 and ld50 on a frequency response graph. To be able to calculate the therapeutic index of drugs and ascertain whether a drug is safe. To define the specific contributions of disease, genetics, and the environment to the variability in drug response. In an ideal world, the response to medications would be the same for every patient. Unfortunately in reality, response to medications is quite variable between patients. Because response to medications is variable, every patient"s response must be evaluated to ensure an adequate therapeutic response. The response to medication is influenced by genetics, disease state, and the environment: environmental factors diet, exercise, smoking, etc, genetics factors gender, race, polymorphisms, etc, disease state factors cardiovascular disease, renal disease, hepatic disease, etc. In 300 500 patients with the disorder. Short term trial to determine efficacy and side effects. 500 5000 patients with the target disorder.