Pharmacology 2060A/B Lecture Notes - Lecture 8: Tachyphylaxis, European Credit Transfer And Accumulation System
3 Mar 2016
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In# summary,# in# addition# to# accounting# for# the# number# of# receptors# occupied,# the# modified# occupancy#theory#takes#into#account#the#affinity#of#the#drug#for#the#receptor#and#the#ability#of# the#drug#to#activate#the#receptor. # 8. 2-classification-of-drug-receptor-interactions: after# a# drug# binds# to# a# receptor# it# can# either# activate#the#receptor#or#block#other#ligands#from# binding#to#the#receptor. # Agonist# a# molecule# that# binds# to# a# receptor# and# activates# it. # agonists# mimic# the# action# of# endogenous# ligands## Antagonists# # molecules# that# bind# to# a# receptor# but# do# not#activate#it. ### Since# agonists# are# molecules# that# activate# receptors,# endogenous# molecules# that# activate# receptors#are#considered#agonists. ##some#of#these#include#neurotransmitters#and#hormones. : drugs# that# we# design# as# agonists# are# often# targeted# to# mimic# the# action# of# the# body"s# endogenous#molecules. , agonists#can#be#thought#of#as#having#both#affinity# And# intrinsic# activity# since# they# are# able# to# bind# and#activate#a#receptor. # It# is# important# to# note# that# the# action# of# an# agonist# does# not# always# increase# a# physiological# response# (i. e. # heart# rate). # # agonists# may# cause# either# increased# or# decreased# physiological# response#depending#which#receptor#is#activated. # Some# agonists# can# bind# to# different# receptors# (remember# specificity)# and# therefore# may# cause# different#effects#depending#on#the#dose. ##a#good# example# of# this# is# dopamine,# an# endogenous# neurotransmitter#that#we#also#give#as#a#drug. #
