Pharmacology 2060A/B Lecture Notes - Lecture 1: Clinical Trial, Pharmacology, Pharmacokinetics
26 May 2016
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Document Summary
The study of drugs includes: how the drug is delivered (route of administration, how it works (mechanism of action, therapeutic effects, adverse effects. Classi cations: chemical agents (traditional, biological (antibodies, hormones, natural (vitamins, herbals) How drugs enter the body: enteral: involve gastrointestinal tracts. Rectal: parenteral: do not involve gastrointestinal systems, injections. Subcutaneous: topical: on surface of skin. Pharmacokinetics: what the body does to the drug, encompasses (adme) Absorption: for oral, drug is swallowed and absorbed through the stomach or small intestine. Distribution: once in the liver, distributed to other organs (metabolism proceeds distribution) Metabolism: the liver is the primary site of drug metabolism. From here, the drug may either enter systemic circulation (enter tissues such as the heart, brain, muscle, kidney--->primary excretion organ), or may enter the bile duct (another route of excretion) Excretion: peed out if enters kidneys, or pooped out if enter bile duct (enter bile duct, go back to intestine, excrete).
