Pharmacology 2060A/B Lecture Notes - Lecture 3: Hydrophile, Malnutrition, Bile Canaliculus
8 Aug 2016
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Document Summary
Drugs distribute into compartments in the body where they may be stored, metabolized, excreted or exert their pharmacological effect. Interstitial space- the extracellular fluid that surrounds the cells. Low molecular weight, water soluble drugs distribute in the interstitial space: total body water- includes the fluid in the interstitial space, intracellular fluid and the plasma, plasma- the non-cell containing component of blood. Drugs strongly bound to plasma protein and high molecular weight drugs typically distribute in plasma: adipose tissue- the body"s fat. Lipid soluble (lipophilic) drugs distribute into adipose tissue: muscle- some drugs bind tightly to muscle tissue, bone- some drugs absorb onto the crystal surface of bone with eventful incorporation into the crystal lattice. Bone can be a reservoir for the slow release of some drugs: other tissues. Determined by: blood flow to tissues, ability of drug to move out of capillaries, ability of drug to move into cells.
