Pharmacology 3620 Lecture Notes - Lecture 6: Tyrosine-Kinase Inhibitor, Imatinib, Hyperbola

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5 Oct 2016

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Pharmacodynamics: the quantitative description of the effect of a drug on the body at the site of action. o. Most drugs exert their effects by binding to specialized macromolecules (i. e. receptors and enzymes) o. Pharmacokinetics and pharmacodynamics are both important branches in determining how a drug acts. o. Pharmacokinetics is necessary in determining how a drug gets into the blood and then to the site of action. Drugs can be thought of as signals that we send to the cell. Receptors can be thought of as detectors which detect the signal. In the simplest schematic, when receptors are empty, they do not influence intracellular processes. When a drug is bound to a receptor, the receptor becomes activated and produces a response. Many drugs mimic endogenous ligands, some drugs block receptors. Note: a ligand is a molecule that binds to a receptor; can be a drug or endogenous molecule.

Related Questions

QUESTION 1

A partial agonist would:

		a) Have lower efficacy than a full agonist
		b) Would be less effective at stabilizing the active form of a receptor than a full agonist
		c) Would have greater intrinsic activity than an antagonist
		d) All of the above

QUESTION 2

The presence of spare receptors means that a drug would:

		a) Would have its potency unchanged by low levels of noncompetitive antagonists
		b) Still maintain its maximal efficacy at low concentrations of noncompetitive antagonists
		c) Achieve its maximal response without occupying all available receptors
		d) A and C
		e) B and C

QUESTION 3

A competitive antagonist would:

		a) Increase drug potency
		b) Decrease drug efficacy
		c) Decrease drug potency
		d) Increase drug efficacy

QUESTION 4

pH trapping explains:

		a) Why drugs will break down when exposed to acidic conditions
		b) Why drugs do not diffuse back and forth between the kidneys and circulation
		c) Why drugs are attracted to adipose tissue
		d) How drugs are metabolized

QUESTION 5

An ideal drug would have:

		a) High potency, high efficacy, and a large therapeutic index
		b) High potency, high efficacy, and a small therapeutic index
		c) A high ED50, high efficacy, and a large therapeutic index
		d) High intrinsic activity, low affinity, and a low LD50

QUESTION 6

Which of the following is most likely to cross the membrane of a cell?

		a) A nonpolar compound
		b) A polar compound
		c) A charged compound
		d) A large compound

QUESTION 7

Which is not a pharmacodynamic process?

		a) Absorption
		b) Excretion
		c) Metabolism
		d) Digestion

QUESTION 8

A drug with a low Vd would:

		a) Be less likely to bind to plasma proteins
		b) Have a higher rate of clearance
		c) Disseminate widely through tissues
		d) Remain primarily within the circulation

QUESTION 9

First-pass metabolism does not occur through which method of drug administration?

		a) Intramuscular
		b) Intravenous
		c) Transdermal
		d) Enteral

QUESTION 10

A drug with greater efficacy would:

		a) Have a greater maximal response
		b) Require a lower dose to reach its maximal effect
		c) Be less toxic
		d) All of the above

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Pharmacology 3620 Lecture Notes - Lecture 6: Tyrosine-Kinase Inhibitor, Imatinib, Hyperbola

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