Pharmacology 3620 Lecture Notes - Lecture 17: Phosphatidylinositol, Inositol Trisphosphate, Diglyceride
29 Dec 2016
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Major depressive disorder (mdd) (unipolar depression: characterized by: And/or a loss of interest and pleasure in nearly all activities: often associated with: Changes in appetite; sleep disturbances; decreased psychomotor activity; decreased energy and feelings of worthlessness; difficulty concentration & making decisions; thoughts of death: up to 15% of these persons with this form of depression will die by suicide. Wide, cyclic fluctuations in mood between depressed phase and manic phase: the depressed phase will be similar to unipolar depression disorder, the manic phase can cause someone to do any/all of the following behaviours: Elevated; expansive; irritable, which may include inflated self-esteem; a decreased need for sleep; increased tendency to talk. Major classes of drugs for treatment of depression: Selective serotonin reuptake inhibitors (ssris: only effective for 50-60% of people with mdd, often used in conjunction with other psychtherapy techniques. Tricyclic antidepressants (tcas) (work on both ne and serotonin with no selectivity for either molecule)
