Pharmacology 3620 Lecture Notes - Lecture 15: Benzodiazepine, Ligand-Gated Ion Channel, Absence Seizure
6 Jan 2021
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Modify na+ vg channel activity: decreases ap firing, example: local anesthetics like lidocaine, lidocaine blocks the na+ vg channel pore by keeping the activation gate closed. Nt is not released into the synaptic cleft: without ach in the synaptic cleft, there is no muscle contraction. If this enzyme is inhibited, monoamines are not broken down; instead, they are repackaged back into vesicles allows for a sustained signal: example: donepezil, used to treat dementia. In ad, there is a decrease in the amount of ach signaling: ach is broken down in the synaptic cleft by ache, donepezil is an ache inhibitor, which decreases ach breakdown. Neurotransmitters: acetylcholine alzheimer"s, some movement disorders, noradrenaline anxiety, depression, serotonin anxiety, depression, schizophrenia, dopamine parkinson"s, schizophrenia, glutamate epilepsy, alzheimer"s, schizophrenia, gaba anxiety, epilepsy. What might be an adverse effect: the person may show symptoms of schizophrenia, antagonists: schizophrenia and bipolar (many atypical psychotics: d2, glutamate receptors, several types.
