Pharmacology 3620 Lecture Notes - Lecture 17: Anxiogenic, Thalamus, Meta-Chlorophenylpiperazine

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Normal anxiety: is valuable as it prepares us to deal with a potential threat. This can take the form of two basic emotions, fear and anxiety. Fear: can be thought of as that emotion which prepares us to respond to an immediate threat by fighting or running. Anxiety: is a more diffuse emotion that involves perception of less immediate (future) consequences of a situation in the environment. i. e. uncertainty, unknowing or ignorance of a future scenario. Abnormal anxiety: is the inappropriate behaviour in response to threats that are either not real or the behaviour is disproportionate to the situation. To date there is no well-defined neurobiological correlate to anxiety, like depression our knowledge of it is derives from successful and failed therapeutics. Panic disorder: considerable debate existed through the 50 and 60"s as whether severe agoraphobia and fear were just another manifestation of the continuum of schizophrenic symptoms. Several lines of evidence suggested that this is not so.

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