Pharmacology 3620 Lecture Notes - Lecture 3: Thiopurine Methyltransferase, Glucuronide, P-Glycoprotein
9 Dec 2015
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Document Summary
Pharmacogenetics: study of the genetic basis for variation in drug response. determined by a this gene that codes for a taste receptor on the tongue. In 1930"s, rst studies relating to genetic control of a taste response occurred. Ptc tasting: ptc gene" discovered in 2003 called tas2r38 - ability to taste ptc is. Antipyrine metabolism: old drug that used to be used as an analgesic and antipyretic agent. mediated metabolism. Metabolized by a lot of cyps so its a sloppy" probe drug but good indicator for general gyp. Single nucleotide polymorphisms (snp): base pair substitutions that occurring the population. Types of genetic variation: at an allele frequency 1% or greater. rarely alters amino acid). Sense/synonymous: does not alter the amino acid (substitutions in 3rd base pair. Snps in regulatory regions may a ect level of mrna by a ecting rate of transcription. Insertions/deletions: one or more nucleotides added/taken from a gene.
