Pharmacology 3620 Lecture Notes - Lecture 3: Glucose Tolerance Test, Diabetes Mellitus Type 1, Pancreas

• School: Western University
• Department: Pharmacology
• Course: Pharmacology 3620
• Professor: Michael A Cook

Document Summary

Whether cells use glucose or faty acids to generate atp depends on whether an organism is: Glucose used to generate atp in most issues. Excess stored as glycogen in the liver and skeletal muscle. Glucose uptake goes up in adipocytes and muscle. Fas used to generate atp in most issues (from lipolysis) Glycogenolysis in liver and muscle (make glucose from glycogen) Gluconeogenesis in the liver (make glucose from lacic acid, amino acids, and glycerol) Lipolysis, glucogenolysis, and gluconeogenesis all go up in the liver. Glucose uptake and metabolism (and blood glucose concentraions) Tightly controlled by pepide hormones produced by the pancreas. Digesive enzymes produced by the exocrine pancreas enter the intesine via the bile duct. Remember: alpha (glucagon) and beta (insulin) cells (endocrine) and acinar cells (exocrine; proteases, amylase, lipase, nucleases) Beta cells: release insulin in response to high blood glucose. Alpha cells: release glucagon in response to low blood glucose.