Pharmacology 3620 Lecture Notes - Lecture 5: Steroidogenic Acute Regulatory Protein, Zona Glomerulosa, Zona Reticularis
4 Apr 2016
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Document Summary
Endocrine pharm: drugs used in inlammatory diseases and osteoporosis. Focus: crh released by the hypothalamus acts on cells of the anterior pituitary leading to the producion of acth (adrenocoricotropic hormone) Acth acts on cells of the adrenal glands to simulate the producion of several steroid hormones. Each adrenal gland consists of 2 disinct endocrine glands: adrenal cortex and adrenal medulla. Adrenal medulla: inner / releases epinephrine and norepinephrine. 3 layers in the cortex: from upper to inner / zona glomerulosa, zona fasciculate, and zona reicularis. Zona glomerulosa: site of aldosterone synthase and releases aldosterone. Zona reicularis: site of 11beta-hydroylase and 17alpha-hydroxylase and releases corisol and androgens. Simulaion of the hypothalamic-pituitary-adrenal axis results in the secreion of steroid hormones. Crh binds receptors on the surface of endocrine cells of the anterior pituitary. Crh induces synthesis of proopiomelanocorin is post-translaionally processed to adrenocoricotropic hormone (acth)
