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Oxygen transport

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Physiology 3120
Tom Stavraky

Human Physiology Friday, February 5, 2010 “Respiration IV” Oxygen Transport • Transported (I) as a dissolved gas (minor component), or (II) bound to haemoglobin • Binding to haemoglobin  Major component  Bound = oxy-H; unbound = deoxy-H  4 subunits, each with heme group (has an iron molecule to which O can bind)  1g haemoglobin can carry 1.34mL oxygen  O capacity of blood  perform experiment; have blood equilibrate and measure the amount bound to H  H-O dissociation curve  In the lung, the H saturation is almost 100% (at 100mmHg)  If the PO drops in the lung, still have high saturation (at 60mmHg, saturation is still 90% or so); not a linear curve  PO in tissue is low, and there is a steep drop in affinity, which allows dissociation of O in tissues  Shape is “sigmoidal”; results from binding of H to O; binding one O molecule is hard, but once it binds, the other 3 O’s can bind relatively easily  Factors that influence it. . .(doesn’t transform curve, but only shifts it) • Shifted to the right; at the same partial pressure, you have less saturation • P-CO (2hifts right); higher T (
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