Physiology 2130 Lecture Notes - Lecture 11: Distal Convoluted Tubule, Proximal Tubule, Renal Function
7 Aug 2017
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Document Summary
Blood supply of the kidneys: renal artery interlobar arteries arcuate arteries interlobular arteries interlobular veins arcua vein, interlobar vein renal vein. The renal corpuscle made up of glomerular capsule and glomerulus: blood filtration occurs here, facilitated by a highly permeable capillary endothelium surrounded by podocytes. Large diameter afferent arteriole and small diameter efferent arteriole also enhance glomerular filtration. Glomerular filtration rate (gfr) and filtered load the volume of fluid filtered by the glomerulus during a certain time period (filtered load = 1 day) Eq1: filter load = gfr x plasma concentration of the substance. Note: glucose almost completely filtered by glomerulus but is reabsorbed by nephron in healthy people. Tubular transport mechanisms secretion: generally hormone regulated but can occur without hormone control, secreted substances are k+ and h, this process relies on the na+/k+ pump. Na+ reabsorption takes place in the proximal tubule, ascending limp of loop of henle and early distal tubule mostly by non-regulated mechanisms.
