Physiology 3120 Lecture Notes - Lecture 3: Molality, Homeostasis, Sodium Chloride
13 Oct 2017
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Document Summary
A form of carrier mediated transport: chemical specificity: only carry a particular molecule across, then can thus be competitively inhibited, saturation kinetics. Moves substances against the concentration gradient: requires atp, e. g. Pumps 3 na+ out and 2 k+ in against the concentration gradient for. At rest all binding sites empty, although it is pretty much always working in vitro: atp is attached but not split. Metabolic inhibitors can block the na+/k+ pump: ouabain (from poison arrow tree, high enough dose can kill a hippo, african rat: uses poison to repel predators, hair is also porous now, digoxin (from foxglove plant, affect the heart. Inhibitors like these function by binding to the ion pathway not necessarily the receptors usually between steps 3 and 4 prevents k+ binding from when pump open to extracellular side. Basal side (on the right) facing interstitial space.
