Physiology 3120 Lecture Notes - Lecture 16: Emulsion, Triglyceride, Chylomicron

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Woods Lecture 16
Best way to absorb protein is single amino acid, but we can also absorb as di or tripeptides. Dif
than CHO’s (only single saccharides). As babies> can absorb whole proteins> lose this ability
-majority of protein digestion within small intestine (even tho pepsin cuts in stomach) in
Pancreatic enzymes from acinar cells
-enterokinase is a bb enzyme > form trypsin from trypsinogen > limitting step is enterokinase to
produce trypsin > to make the other ximogens
-20 dif amino acids (neutral acidic, or basic amino acids)> so they have dif properties > need to
have more enzymes to recognize them to cleave down into amino acids
Aminopeptidase cleaves last amino acid off, regardless of what the a acid is same for
carboxypeptidase at C end
This is not efficient but we can liberate single amino acids
-enpeptidases are specific : target seq they recognize
-pepsin, trypisin, chymotrypsin, elastase: all endopeptidases
Hopefully after will be recognized again and cut by endo and exopeptidaes
Vast majority are cotransporters with sodium
-not all amino transporters are cotransport with sodium
Single amino acids absorbed into cell > amino acid sodium exchanger > not uniporter
-exchange on basolat membrane
Single amino acid cotransport with sodium is man transport for single amino acids
-can move di and tripeptides across mem> cotransport with H (proton cotransporter)> same
transporter can recognize all dipeptide combos> proton provided from Sodium hydrogen
exchanger (proton into cell has favourable gradient)
-most of time never transport dipeptides across basolat mem
-usually peptidases digest them in cell
-some can > in exchange for H > for dipeptides
Ab’s: you can absorb entire proteins like AB’s from mother > transcytosis of AB’s to get passive
immunity> but this might be one of the reasons we get food allergies> instead transcytosing
food proteins > get allergy to it (not always the case with allergies, bc can get allergies without
this happening , but it’s one of the things that can happen
-they believe it stops at 6-9months old > now cant do whole proteins> but single amino acids,
and di-tripeptides
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