Physiology 3140A Lecture Notes - Lecture 2: Dna-Binding Domain, Nuclear Localization Sequence, Tata-Binding Protein
3 Jul 2017
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What is a transcription factor: proteins that control rates of transcription they do not necessarily have to bind dna, rna poly ii is not a transcription factor, there are two types, general transcription factors. Initiate gene expression and binds all genes: tfii proteins and tata binding proteins. Initiates particular gene expression by opening up promoter region making gene available to be transcribed: specific transcription factors. E2f transcription factor 1 (examples in brackets: one of the first tfs indentified, has nls to target to nucleus, many tfs will have multiple tads. Ie. binding sites for other tfs (prb) which would inhibit expression. Interaction with co-activator (cbp: cbp protein causes histone acetylation, phosphorylated sites throughout domain can either promote or repress activation, this tf is the target of kinase activity. How are tfs classified: based on their structure, what they bind to and their homology (similarity among themselves).
