Physiology 3140A Lecture Notes - Lecture 4: Cre Recombinase, Tamoxifen, Diabetes Mellitus Type 1
3 Jul 2017
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Significance of tfs: they regulate developmental processes many developmental disorders are linked to tfs. Epigenetics 3 general types: modifications of histone core proteins, phosphorylation, ubiqunation, methylation, sumolation, acetylation. Some proteins can have two functions, they can write and read, or read and erase. Both a and b use the same nuclear receptor but they recruit different tfs depending on whether the agonist is bound. In a, the agonist is bound, recruits coactivators which then recruit the histone acetylation enzymes. In b, the agonist is not bound, recruits corepressors which then recruit this histone deacetylation enzymes. Active methylation: trimethylation of h3k4 increased gene expression, mixed lineage leukemia (mll) proteins catalyze methylation of h3k4 sites. In diagram, mll are the writers, jarid are the erasers. Repressive methylation: trimethylation of h3k27 decreases gene expression, polycomb repressor complex 2 (prc2) catalyzes the methylation of h3k27. Lower expression in diagram, jmjd are the erasers, prc2 are the writers.
