Physiology 3140A Lecture Notes - Lecture 3: Tata Box, Transcription Factor Ii B, Consensus Sequence
3 Jul 2017
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Document Summary
What are different regions of the genome: genes introns and exons, promoters, enhancers. Intergenic regions garbage, regulatory regions, non-coding regions - transcribed but not translated: majority of dna is transcribed into rna just not preserved or translated into functional protein. Central dogma of biology: dna rna protein: evidence suggests this is not unidirectional, rna can make dna, proteins can affect rnas. Dna is transcribed to pre-mrna (before this is even fully made, splicing occurs) Enhancers found in intergenic dna: can be found anywhere in the genome and in any gene, does(cid:374)"t ha(cid:448)e to (cid:271)e ph(cid:455)si(cid:272)all(cid:455) lo(cid:272)ated next to the gene it regulates, can even be on different chromosomes. Digestive enzymes are expressed in pancreas, not in lungs/brain: their promoters contain similar motifs which bind specific tfs that are only expressed in the pancreas, general (basal) transcription factors can bind to promoters not tissue specific.
