Physiology 3140A Lecture Notes - Lecture 6: Histone Acetyltransferase, Pd-L1, Chemotherapy
3 Jul 2017
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Lecture 6 fuck this guy and his interesting questions. Won"t there be significant off target effects when inhibiting histone acetyltransferase (hats), histone deacetylases (hdacs), histone methylases (hmts) and dna methyltransferases (dmnt): yes, but the goal of chemotherapies is to kill cancer cells without killing the patient. Side effects of whatever drug you use will also affect many tissues that are actively dividing that are not cancerous (hair, gi tract etc. ) Many developmental disorders as a result of epigenetic silencing (intellectual disabilities specifically) he has a whole chart of shit in his lecture but fuck that. T-cells need apc (antigen presenting cell) to activate it it then binds to cells that would trigger a death response to kill tumour cells. Chemotherapeutic agents attempt to bind the ctla-4 receptor allowing for the normal receptor to bind to t-cell. They can also target the ligands secreted by tumour cells that inhibit pd-l1.
