Physiology 3140A Lecture Notes - Lecture 6: Sh3 Domain, Grb2, Arrestin

• School: Western University
• Department: Physiology
• Course: Physiology 3140A
• Professor: John Di Guglielmo

Document Summary

Any involved in mapk pathway: sh2 domain recognizes specific phosphotyrosine motifs, ex. Grb2 binding to: sh3 domain binds proline rich domains in intracellular proteins, ex. Src: proto-oncogene, non-receptor tyrosine-protein kinase: regulates embryonic development and cell growth, proto-oncogenes are genes that cause normal cells to become cancerous when they are mutated. Compartmentalization of mapk signals by scaffolds ex. Mapk pathway: why would you want to limit cross-talk between map-kinase, do(cid:374)"t (cid:449)a(cid:374)t o(cid:374)e path(cid:449)a(cid:455) to affect (cid:449)hat happe(cid:374)s to the other path(cid:449)a(cid:455). I(cid:374) this case (cid:894)mapk path(cid:449)a(cid:455)(cid:895) mating factor activates mapk pathway (cid:373)ati(cid:374)g respo(cid:374)se; (cid:455)ou (cid:449)ould(cid:374)"t (cid:449)a(cid:374)t gl(cid:455)cerol s(cid:455)(cid:374)thesis production (which is also activated by mapk pathway) Akt promotes cell survival mtor regulator of cell metabolism, growth, proliferation, survival (serine-threonine kinase) Stat signal transducer and activator of transcription: pi3k, stat both must have sh2 domains to bind tyrosine-kinase domain, ptem is mutated in many cancers.